Saturday, May 11, 2013

Israel police guard women praying at Jewish site

JERUSALEM (AP) ? Israeli police with metal barriers and human chains on Friday held back thousands of ultra-Orthodox protesters who tried to prevent a liberal Jewish women's group from praying at a key holy site, the first time police have come down on the side of the women and not the protesters.

The switch followed a court order backing the right of the women to pray at the Western Wall in the Old City with practices Orthodox Jews insist are the role of men alone.

The "Women of the Wall" group has been holding monthly prayer services on the first day of the Hebrew month at the Western Wall in Jerusalem for more than two decades, wearing prayer shawls and performing religious rituals reserved for men under Orthodox Judaism. Accused by ultra-Orthodox leaders of violating "local custom" at the holy site, many of the group's members have been arrested.

On Friday the tables were turned because of the court ruling. Police protected the women and arrested three ultra-Orthodox men for disorderly conduct, police spokesman Micky Rosenfeld said.

It's a turning point for the group. Along with the arrests, the women have faced heckling and legal battles in a struggle to attain what they say is their right: to worship at the wall ? the holiest place where Jews can pray ? as men do. Then last month a Jerusalem court instructed police to stop detaining the women.

"It's a historic moment," said Shira Pruce, a spokeswoman for Women of the Wall. "The police did an amazing job protecting women to pray freely at the Western Wall. This is justice."

The plaza just in front of the Western Wall, a remnant of the biblical Jewish Temples, is marked off into two distinct sections, one for men and the other for women, where they pray separately. Up to now, women have had to abide by the Orthodox strictures of prayer.

Under Orthodox Jewish practice, only men may wear prayer shawls and skullcaps, and most Orthodox Jews insist that only men should carry a Torah scroll. The more liberal Reform and Conservative streams of Judaism, marginal in Israel but the largest denominations in the United States, allow women to practice the same way as men do in Orthodox Judaism. They are ordained as rabbis, lead services, read from the Torah and wear prayer shawls.

Israel's ultra-Orthodox establishment opposes any inroads from these groups, fearing their customs and authority could be eroded. They have argued that visitors to the Western Wall, whose rabbi is ultra-Orthodox, must respect the local practices.

Israeli media reported that before Friday's prayer service, some rabbis called on followers to flood the Western Wall in a bid to block the women from reaching the site.

Israeli TV video showed a packed Western Wall plaza with police forming a ring around the women and others shoving back ultra-Orthodox men. Female police officers had aligned in a human chain around young women protesters who were peering out at the Women of the Wall.

Pruce said police escorted the Women of the Wall out of the area after they finished their service and boarded them on buses, which were then pelted with stones as they left the Old City.

The Western Wall rabbi, Shmuel Rabinowitz, who has in the past called the women's group a "provocation," tried to ease tensions at the holy place. "No one in Israel wants a disagreement at the Western Wall," Rabinowitz told Israel Army Radio.

Israeli officials and lawmakers have been attempting to find a compromise that will satisfy both the women's group and the ultra-Orthodox. They have proposed establishing a new section at the Western Wall where men and women can pray together. The proposal, if implemented, would be seen as a victory for the more liberal streams of Judaism, which have been battling to be granted recognition in Israel.

The Women of the Wall, in contrast, insist on their right to pray as they want in the current women's section.

It's part of a wider culture clash that has triggered a backlash against Israel's ultra-Orthodox community.

The ultra-Orthodox make up about 10 percent of Israel's 8 million citizens. For most of the last three decades, they have served in coalition governments, securing vast budgets for religious schools and exemptions from mandatory military service for tens of thousands of young men in full-time religious studies.

The system has bred widespread resentment among the secular and modern Orthodox majority. It became a central issue in January parliamentary elections, and ultra-Orthodox parties were eventually left out of the government.

Many Israelis also feel the ultra-Orthodox attempt to impose their values on the rest of society, with their activists pushing for gender-segregated buses and sidewalks, defacing billboards showing women or trying to force women to dress modestly.

This week, Israel's attorney general urged Cabinet ministers to take measures to end gender segregation. Then on Thursday, Israeli Justice Minister Tzipi Livni said she has instructed her staff to draft a bill that would make the segregation and humiliation of women in public a criminal offense.

"The dismissal of women from the public sphere harms not only their dignity, but also harms us as a society that aspires toward equality," Livni wrote on her Facebook page.

Source: http://news.yahoo.com/israel-police-guard-women-praying-jewish-070503660.html

obama slow jams the news metta world peace ron artest gladys knight private practice

VANCOUVER: Hotels on Parade

With travel being the essence of inspiration, it is critical to enjoy yourself ? and the hotel you choose is quite the determining factor. After six years in the making, the Vancouver Art Gallery has finally unveiled Grand Hotel: Redesigning Modern Life, a retrospective of the hotel and its evolution from a utilitarian structure to a cultural phenomenon. Describing hotels as the ?defining structures of the modern age,? the exhibition reflects on the physical and psychological dimensions of the hotel using four main themes ? Travel, Design, Social, and Culture. Inspired by the 1932 film Grand Hotel, this fascinating exhibition spans three centuries and presents interrelated stories of guests over the years, for a unique perspective on travel culture. ? Sarah Ryan Hecht

Grand Hotel: Redesigning Modern Life

On view through September 15th at the Vancouver Art Gallery

750 Hornby Street, Vancouver, BC V6Z 2H7

604 662 4700

Photos courtesy of We Heart

Source: http://blog.stylesight.com/travel/vancouver-hotels-on-parade

paul williams paul babeu kevin costner budweiser shootout animal house invincible

Friday, May 3, 2013

Blockbuster releases On Demand video streaming app for iOS

Image

Blockbuster announced its entrance back into the video streaming game in January after pledging to exit that market late last year. Today, Blockbuster's reincarnation as a video streaming service continues, as the company rolled out its On Demand app for iOS, bringing "thousands" of movies to iPads and iPhones running iOS 4.3 and up. By adding Apple devices to the fold, Blockbuster can now shoot movies to the majority of mobile devices -- previously it was only available for Android (plus Mac, PC, Roku and Samsung Smart TVs). So, if you're looking for 1080p video with 5.1 surround streaming to your Apple-fied mobile screen, your download awaits.

Filed under: , , ,

Comments

Via: 9to5 Mac

Source: App Store

Source: http://feeds.engadget.com/~r/weblogsinc/engadget/~3/Bf738RcVF78/

super bowl commercials wheres my refund Fast And Furious 6 superbowl ads Super Bowl Ads 2013 Buffalo Wild Wings Superbowl Start Time

Signs of recovery seen blunting opposition to UBS pay

By Katharina Bart

ZURICH (Reuters) - Strong first-quarter results are likely to ensure UBS wins shareholder backing for its pay plans at a meeting on Thursday, though a $26 million signing-on award for investment bank chief Andrea Orcel is bound to attract criticism.

Former Bundesbank president Axel Weber, who has been chairman of the Swiss bank for the past year, will have the job of handling any opposition. And some of it could be personal, after he pocketed 4 million Swiss francs ($4.3 million) for joining, on top of his basic pay and an award of UBS shares.

Fed up with corporate excess, Swiss voters pushed through some of the strictest controls on executive pay this year, including the introduction of binding shareholder votes on compensation from next year.

"Chairman Weber talks of a new corporate culture and that managers should set an example, but he himself is taking eight million Swiss francs," retail investor Brigitta Moser-Harder, who has campaigned against UBS bonuses, told Reuters.

Banker pay and bonuses have become hot topics across Europe since the financial crisis, when a string of major banks including UBS had to be bailed out by taxpayers.

Earlier this month, shareholders at Julius Baer rejected the Swiss private bank's pay plan, while a sizable minority of investors were critical of a move by Credit Suisse to issue new shares to pay staff bonuses.

A $2.3 billion loss due to a rogue-trading scandal and a record $1.5 billion fine for its part in a global interest rate rigging scandal have singled UBS out for opprobrium.

Last year, over a third of shareholders rejected the bank's pay plans and only the thinnest of majorities approved the performance of the board and management.

This time round, opposition is likely to be more muted after first-quarter results signaled UBS's plans to scale back its investment bank and focus on private banking are paying off.

Shareholder advisory group ISS has also recommended backing UBS's pay plan.

However, individual investors are certain to berate the board for what they see as an alarming asymmetry between UBS's 2.51 billion-franc loss for 2012 and its 2.5 billion bonus pool.

ISS has also warned UBS needs to introduce bonus caps for top executives next year, and that if it does not, it will strongly consider a recommendation to vote against its pay plan.

Unlike other European lenders with investment banking divisions such as HSBC and Barclays , UBS does not have a fixed ratio between bonuses and base salary for executive directors and is instead waiting for Europe to finalize rules on banker bonuses before making any changes.

From January 2014, banker bonuses in Europe will be limited to a maximum two-and-a-half times base salary.

UBS has halved the immediate cash bonuses to executive board members to $1 million and lengthened the deferral period for bonuses in UBS shares. It can also claw back bonuses.

($1 = 0.9290 Swiss francs)

(Additional reporting by Christopher Vellacott; Editing by Carmel Crimmins and Mark Potter)

Source: http://news.yahoo.com/signs-recovery-seen-blunting-opposition-ubs-pay-230153591.html

houston weather dwyane wade the night they drove old dixie down levon robbie robertson the curious case of benjamin button secret service prostitute

Brother bouts, Fox fights and more: Four fights you ?May? get excited for

After a busy run in April, May is a relatively slow month for MMA. You can spend the extra time and money you're not spending on fights on a Mother's Day gift. After you've taken your mother to brunch, check out these fights:

Mike Treadwell vs. Chris Treadwell, MFC 37, May 10: This is the brother vs. brother bout. Watch and record it on AXS, then record it. When you and your brother fight during that Mother's Day brunch, show the fight and tell your mom it could be much worse.

Costa Philippou vs. Ronaldo "Jacare" Souza, UFC on FX 8, May 18: Philippou is riding a five-fight win streak, with his last bout a TKO over Tim Boetsch. Souza is one of the latest Strikeforce imports, and he has a three-fight win streak, a nasty ground game and striking that gets more impressive with every game. Check it out before the Vitor Belfort-Luke Rockhold bout.

Fallon Fox vs. Allannah Jones, Championship Fighting Alliance, May 24: No matter your feelings on Fallon Fox, you probably want to see her fight. Some want to see her get knocked out. Some want to see how the first openly trans fighter has handled the spotlight. You can see her bout with Allannah Jones at Championship Fighting Alliance 11 which will air on AXS TV. Fox-Jones is on the undercard of the event headlined by Strikeforce standout Mike Kyle and Alistair Overeem's brother Valentijn.

Every single bout on UFC 160, May 25: The limited quantity of UFC bouts in May is made up for by the quality of fights at UFC 160. It starts with the main event. Cain Velasquez will test his title in a rematch with Antonio "Bigfoot" Silva, and former champ Junior dos Santos will fight Mark Hunt in a another heavyweight bout. T.J. Grant and Gray Maynard are fighting for the next lightweight title shot. Even the preliminary card has fighters that are really fun to watch, like Khabib Nurmagomedov and Brian Bowles.

Source: http://sports.yahoo.com/blogs/mma-cagewriter/brother-bouts-fox-fights-more-four-fights-may-194805950.html

Salwa Amin Grammys 2013 2013 Grammy Winners abraham lincoln Chris Dorner 1800 Flowers walking dead

Music City mourns country legend George Jones

NASHVILLE, Tenn. (AP) ? For a guy who sang so many sad songs, George Jones left behind a lot of laughs.

There was more humor than sadness at Jones' funeral Thursday at the Grand Ole Opry House as thousands gathered in Nashville ? some arriving hours before sunrise ? to pay their respects to the man whose voice has defined country music for more than half a century.

Friend after friend related stories of Jones' kindness, his love for his widow, Nancy, who's credited with helping him survive his personal demons later in life, and the funny little moments that will stick with them always.

Barbara Mandrell remembered the kindnesses he gave a scared 13-year-old girl just getting her start in the business. Former first lady Laura Bush remembered dumping quarter after quarter into the jukebox to hear "The Race Is On." Wynonna Judd remembered his perfect hair and his friendship. And Vince Gill remembered the man who gave him the nickname "Sweet Pea," a moniker he wasn't sure he liked at first but now treasures.

"The great thing is every time someone calls me Sweet Pea, I'll get to think about him," Gill said before earning a standing ovation for his rendition of "Go Rest High on That Mountain" with Patty Loveless.

The nearly 3-hour memorial was attended by several major country stars and political figures. Nancy Jones sat flanked by Bush and Garth Brooks and Trisha Yearwood. Tennessee Gov. Bill Haslam spoke, as did former Arkansas Gov. Mike Huckabee. CBS host Bob Schieffer recalled a 2009 interview with Jones where the singer's true personality seemed to show through.

"I came away feeling his whole life was a surprise to him and he never quite believed any of it," Schieffer said.

Each of the stars who performed had a personal connection to Jones. Randy Travis, who was anointed a traditional country voice by Jones, sang "Amazing Grace," a song Jones had once put his own personal stamp upon.

"When I heard him do this song, it literally gave me chills," Travis said.

Paisley remembered Jones allowing him to house his first horse on the Jones family farm and the visits the two would have, then sang "Me & Jesus." Kid Rock asked Nancy Jones to imagine Jones was actually singing as he performed "Best of Me," before checking himself to the delight of the crowd.

"I know that's a huge (leap of) imagination," Kid Rock said with an embarrassed smile. "Unshaven, long-haired confused country hip-hop rock 'n' roller trying to sing George Jones."

But it may have been Charlie Daniels who summed up Jones best in a long, beautifully rendered tribute. He noted Jones was probably the most imitated country singer of all time.

"George Jones' voice was a rowdy Saturday night uproar at a back-street beer joint, the heartbroken wail of the one who wakes up to find the other side of the bed empty, the far-off lonesome whistle of the midnight train, the look in the eyes of a young bride as that ring is placed on her finger, the memories of a half-asleep old man dreaming about the good old days," Daniels said. "Lost love, lost innocence, good and bad memories, and experiences that are just too much for a human being to deal with. He sang for us all, the non-stop partiers, the guys who are alone and the girl done wrong, the puppy lovers, the extrovert, the introvert and the guy at the end of the bar who never seems to go home ... George had a song for everybody."

The funeral was broadcast live on cable music television channels CMT and GAC and ? in a nod to simpler times when Jones was at his biggest ? on all local television networks.

The Beaumont, Texas, native was in the midst of a farewell tour that was to have wrapped up with an all-star salute in November in Nashville when he died. He postponed two performances two weeks ago and entered the hospital with a fever and irregular blood pressure. He'd been ill off and on over the previous year.

Jones' pure, matchless baritone defined the sound of country music for a half century, and his death brought universal reaction from the music community and fans. Known for hits like "Who's Gonna Fill Their Shoes," ''White Lightning" and "He Stopped Loving Her Today," which Alan Jackson used to close the memorial, Jones had No. 1s in four decades from the 1950s to the 1980s and "Possum" remained a popular figure in Music City until his death.

"Brother George taught us how to sing with a broken heart," Gill said.

Paisley said even though Jones has passed on, his legacy is still there, ready to inspire. He urged young viewers who might be tuning in to check out Jones' music.

"You must be thinking, 'Boy, they're making a ruckus,'" Paisley said. "I would encourage you if you don't know him, go find him now. Go buy his records and see what all this ruckus is about because it's worth it."

___

Follow AP Music Writer Chris Talbott: http://twitter.com/Chris_Talbott.

Source: http://news.yahoo.com/music-city-mourns-country-legend-george-jones-092652443.html

whitney houston laid to rest daytona bike week mary kay ash tiny houses maya angelou joan of arc tony robbins

Thursday, May 2, 2013

Astronomers Discover New Neighbor Galaxy to the Milky Way

Tiny, faint Leo P may point to additional galaxies hidden in our corner of the cosmos


newly discovered nearby galaxy

HELLO, NEIGHBOR: The newfound galaxy Leo P, which lies some five million light-years away from the Milky Way. Image: From Katherine L. Rhode et al. in The Astronomical Journal, vol. 145, page 149; 2013. Reproduced by permission of the AAS.

In recent years astronomers have extended their view almost to the very edge of the observable universe. With the venerable Hubble Space Telescope researchers have spotted a handful of galaxies so faraway that we see them as they appeared just 400 million years or so after the big bang.

But even as astronomers peer ever deeper into the universe to explore the cosmic frontier, others are finding new realms to explore in our own backyard. Such is the case with Leo P, a dwarf galaxy that astronomers have just discovered in the Milky Way?s vicinity. At a distance of some five million or six million light-years from the Milky Way, Leo P is not quite a next-door neighbor, but on the vast scales of the universe it counts as a neighbor nonetheless.

Intriguingly, Leo P seems to have kept to itself, rarely if ever interacting with other galaxies. So the discovery, detailed in a series of studies in The Astronomical Journal, offers astronomers a rare glimpse at a cosmic object unsullied by disruptive galactic encounters. It also suggests the presence of other small galaxies that await discovery in our corner of the cosmos.

Leo P is one of just a few dozen local galaxies that does not swarm around the Milky Way or its massive sibling Andromeda, each of which has been extensively scanned for companion galaxies in recent years. ?There has been a massive increase in the number of these nearby galaxies? around the Milky Way and Andromeda, says astronomer Alan McConnachie of the National Research Council Canada?s Herzberg Institute of Astrophysics, who did not contribute to the new research. ?There have really been very, very few discoveries of dwarfs that are sort of sitting out in the middle of nowhere.? Those lonely dwarf galaxies, such as Leo P, are hard to spot because they are faint, distant, and could be found anywhere on the sky.

In its cosmic isolation the newfound galaxy appears to have led a relatively serene life, undisturbed by the tugs and twists imparted by the gravitational pull of a larger galaxy. ?It is a product of a sedate environment, away from major galaxies,? says Riccardo Giovanelli of Cornell University, one of the astronomers who discovered Leo P. He and his colleagues first spotted it as a cloud of hydrogen gas with the Arecibo Observatory radio telescope in Puerto Rico, then confirmed the discovery with optical telescopes at Kitt Peak National Observatory in Arizona, which identified individual stars within the galaxy.

Compared with the Milky Way, Leo P is a true pip-squeak. Its stars may number in the hundreds of thousands whereas the Milky Way has hundreds of billions. Nevertheless, Leo P is actively making new stars?it contains a number of bright, blue, newly formed stars as well as a region of ionized gas that indicates the presence of a luminous young star. Its large gas reservoir and current star formation are unusual for such a small galaxy?many of its ilk have had their star-making gas stripped away during encounters with bigger galaxies.

By definition, dwarf galaxies are tiny, McConnachie notes. ?So they?re very sensitive to the things that are going on around them. They get harassed, they get pulled apart, they get stripped of their gas,? he says. ?Chances are, when we look at a galaxy like Leo P, we?re seeing how a dwarf galaxy should look if left to its own devices.? Indeed, the ?P? in the galaxy?s name stands for ?pristine?; the rest refers to the galaxy?s location in the constellation Leo as viewed from Earth.

Large galaxies such as the Milky Way grow by pulling in and cannibalizing dwarf galaxies that draw too close, so the study of small galaxies can shed light on how the giants of the cosmos came to be. ?The small galaxies and the big galaxies have kind of a shared history, if you like,? McConnachie says. ?But all the [dwarfs] that we see have sort of been too messed up to tell us much about the intrinsic properties of the small galaxies.?

Source: http://rss.sciam.com/click.phdo?i=885a89fb94b1ae8d1a9badad76fd7c4d

thomas kinkade pat summit brewers matt cain adastra holocaust remembrance day chesapeake energy

CBS' Moonves dismisses Aereo as 1Q earns top views

(AP) ? CBS Corp. Chief Executive Les Moonves gave an upbeat view of the health of broadcast TV Wednesday as the company reported strong results for the first three months of the year. He also dismissed startup Aereo as an "insignificant player" that was stealing CBS' signal.

Moonves told investors that Aereo has "gotten way too much attention" from the news media. The New York-based company takes broadcast signals for free from the airwaves and charges customers to watch them over computers and mobile devices. That threatens CBS' ability to collect fees from traditional service providers such as cable TV for rights to redistribute its stations' signals.

"We're not losing sleep over it. It is an insignificant player that has a couple thousand (subscribers)," Moonves said on a conference call. "We think ultimately that it goes away."

Broadcasters such as CBS have sued Aereo for copyright infringement, but so far Aereo has managed to keep operating thanks to a preliminary ruling in its favor last month. The company captures signals using thousands of tiny antennas, which it argues is comparable to individuals buying digital antennas for themselves.

Moonves echoed the comments of News Corp. Chief Operating Officer Chase Carey, who said last month that if Aereo gets a legal OK to keep operating, he would consider changing the Fox network to a channel available only through cable and satellite TV services.

Moonves said that making this switch at CBS would be "fairly easy to do" and not that disruptive because 85 percent of people who watch CBS do so through TV providers such as cable and satellite companies. But he added, "I'm very doubtful that happens."

Moonves' comments came as CBS, the maker of shows such as "NCIS: Los Angeles" and "The Good Wife," reported that first-quarter earnings rose 22 percent to $443 million, or 69 cents per share. Excluding a loss from the outdoor billboard business in Europe and Asia, which CBS expects to sell this year, adjusted earnings came to 73 cents per share, 5 cents better than the 68 cents predicted by analysts polled by FactSet.

Revenue rose 6 percent to $4.04 billion, the highest since the company's 2006 split from Viacom Inc. That topped the $4.02 billion expected by analysts.

Advertising revenue grew 8 percent to $2.46 billion, helped by big events such as the Super Bowl and Grammy awards. Excluding these one-time events, the company said ad revenue would have grown in the "low single digit" percentages.

CBS Corp.'s stock rose 50 cents, or 1.1 percent, in after-hours trading to $46.90.

Moonves said that demand for last-minute ad buys on the CBS network was strong. He predicted that both bulk airtime sales and prices would be "up considerably" during the mass sales period ongoing now called the "upfronts." Such price hikes would boost CBS's finances in the final quarter of the year. He said prices would be up in the "high single to low double digit" percentages from a year ago.

Alan Gould, an analyst with investment bank Evercore Partners, said Moonves' comments were reassuring. Gould said the quarterly results were much better than expected.

"I do believe him that CBS will do better than the rest of the industry," he said.

Earlier Wednesday, NBC and Telemundo owner Comcast Corp. said broadcast television revenue fell more than 18 percent to $1.5 billion because the quarter last year included the Super Bowl on NBC. Excluding the Super Bowl, which was on CBS this year, revenue fell 5 percent. Comcast blamed lower prime-time ratings at NBC and lower revenue from content licensing.

ABC and ESPN owner Walt Disney Co. and Fox owner News Corp. are scheduled to report results next week.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/495d344a0d10421e9baa8ee77029cfbd/Article_2013-05-01-US-Earns-CBS/id-b945e71269c2458c84cae7a9bc2e133f

mickael pietrus heart transplant the international preppers geraldo obama trayvon martin pietrus

Large genomic study identifies endometrial cancer subtypes, treatment opportunities

Large genomic study identifies endometrial cancer subtypes, treatment opportunities [ Back to EurekAlert! ] Public release date: 1-May-2013
[ | E-mail | Share Share ]

Contact: Caitlin Hool
hoolc@mskcc.org
212-639-3573
Memorial Sloan-Kettering Cancer Center

NEW YORK, MAY 1, 2013 Endometrial tumors can be reclassified into distinct subtypes based partly on their genomic makeup and may respond to targeted drugs already being tested in clinical trials, according to a large-scale genomic analysis led by researchers at Memorial Sloan-Kettering Cancer Center and other centers within The Cancer Genome Atlas (TCGA) Research Network.

Published in the May 2 issue of the journal Nature, the findings may help doctors more accurately diagnose endometrial cancer and choose treatments that will target genomic mutations in women with endometrioid and uterine serous adenocarcinomas, the two most common types of endometrial cancer. The findings could also guide clinical trials and the development of new drugs.

"These findings have an immediate therapeutic application, as patients with endometrial cancer can be tested routinely to see whether they qualify for a targeted therapy clinical trial," said Memorial Sloan-Kettering gynecologic oncologist Douglas A. Levine, MD, corresponding author on the study, principal investigator of Memorial Sloan-Kettering's TCGA Tissue Source Site, and Co-Chair of TCGA's Endometrial Working Group. "The current landscape of treatment for endometrial cancer is quite chaotic, and this research may provide order to that landscape, especially for more-aggressive endometrial cancers."

Endometrial cancer, which forms in the tissues lining the uterus, is the fourth leading type of cancer among women and the eighth leading cause of cancer death. Endometrioid tumors are usually less aggressive, while uterine serous tumors are more aggressive.

There has been little agreement among doctors over the best treatment approach following surgery for patients with a high risk of recurrence, with decisions relying largely on a tumor's pathology. However, it is difficult for pathologists to reliably differentiate high-grade endometrioid tumors from uterine serous tumors.

According to Dr. Levine, incorporating new genomic information into treatment planning could be a great leap forward, helping to make certain that additional therapies are used effectively and only when necessary.

The analysis of 373 endometrial tumors showed that approximately a quarter of high-grade endometrioid tumors have certain types of genomic alterations also found in uterine serous tumors. This suggests that a significant portion of endometrioid tumors should be treated more aggressively after surgery.

Many of the tumors analyzed had mutations in important cancer-related genes and pathways for which targeted therapies are already being tested in clinical trials for other cancers. For example, 84 percent of the tumors have some alteration in the PI3 kinase pathway, which is implicated in many cancers. Additionally, genomic alterations in uterine serous tumors share many features with ovarian serous and triple-negative breast cancers, suggesting opportunity for shared treatments.

Investigators at Memorial Sloan-Kettering are now translating these findings into clinically useful tests that may be applied to ongoing and planned clinical trials.

A project jointly funded by the National Cancer Institute and the National Human Genome Research Institute, TCGA is one of the most comprehensive national efforts to collect and analyze the largest set of tumor samples to date using state-of-the-art genomic and molecular techniques. Memorial Sloan-Kettering currently houses one of TCGA's Genome Data Analysis Centers, led by computational biologist Chris Sander, PhD, biocomputing manager Nikolaus Schultz, PhD, and molecular pathologist Marc Ladanyi, MD. For the endometrial cancer study, Memorial Sloan-Kettering contributed more than 10 percent of all tissue samples analyzed.

###

This research was supported by the National Cancer Institute of the National Institutes of Health (NIH) under award 5U24CA143840-04.

Memorial Sloan-Kettering Cancer Center is the world's oldest and largest private institution devoted to prevention, patient care, research, and education in cancer. Our scientists and clinicians generate innovative approaches to better understand, diagnose, and treat cancer. Memorial Sloan-Kettering specialists are leaders in biomedical research and in translating the latest research to advance the standard of cancer care worldwide. For more information, go to http://www.mskcc.org.


[ Back to EurekAlert! ] [ | E-mail | Share Share ]

?


AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.


Large genomic study identifies endometrial cancer subtypes, treatment opportunities [ Back to EurekAlert! ] Public release date: 1-May-2013
[ | E-mail | Share Share ]

Contact: Caitlin Hool
hoolc@mskcc.org
212-639-3573
Memorial Sloan-Kettering Cancer Center

NEW YORK, MAY 1, 2013 Endometrial tumors can be reclassified into distinct subtypes based partly on their genomic makeup and may respond to targeted drugs already being tested in clinical trials, according to a large-scale genomic analysis led by researchers at Memorial Sloan-Kettering Cancer Center and other centers within The Cancer Genome Atlas (TCGA) Research Network.

Published in the May 2 issue of the journal Nature, the findings may help doctors more accurately diagnose endometrial cancer and choose treatments that will target genomic mutations in women with endometrioid and uterine serous adenocarcinomas, the two most common types of endometrial cancer. The findings could also guide clinical trials and the development of new drugs.

"These findings have an immediate therapeutic application, as patients with endometrial cancer can be tested routinely to see whether they qualify for a targeted therapy clinical trial," said Memorial Sloan-Kettering gynecologic oncologist Douglas A. Levine, MD, corresponding author on the study, principal investigator of Memorial Sloan-Kettering's TCGA Tissue Source Site, and Co-Chair of TCGA's Endometrial Working Group. "The current landscape of treatment for endometrial cancer is quite chaotic, and this research may provide order to that landscape, especially for more-aggressive endometrial cancers."

Endometrial cancer, which forms in the tissues lining the uterus, is the fourth leading type of cancer among women and the eighth leading cause of cancer death. Endometrioid tumors are usually less aggressive, while uterine serous tumors are more aggressive.

There has been little agreement among doctors over the best treatment approach following surgery for patients with a high risk of recurrence, with decisions relying largely on a tumor's pathology. However, it is difficult for pathologists to reliably differentiate high-grade endometrioid tumors from uterine serous tumors.

According to Dr. Levine, incorporating new genomic information into treatment planning could be a great leap forward, helping to make certain that additional therapies are used effectively and only when necessary.

The analysis of 373 endometrial tumors showed that approximately a quarter of high-grade endometrioid tumors have certain types of genomic alterations also found in uterine serous tumors. This suggests that a significant portion of endometrioid tumors should be treated more aggressively after surgery.

Many of the tumors analyzed had mutations in important cancer-related genes and pathways for which targeted therapies are already being tested in clinical trials for other cancers. For example, 84 percent of the tumors have some alteration in the PI3 kinase pathway, which is implicated in many cancers. Additionally, genomic alterations in uterine serous tumors share many features with ovarian serous and triple-negative breast cancers, suggesting opportunity for shared treatments.

Investigators at Memorial Sloan-Kettering are now translating these findings into clinically useful tests that may be applied to ongoing and planned clinical trials.

A project jointly funded by the National Cancer Institute and the National Human Genome Research Institute, TCGA is one of the most comprehensive national efforts to collect and analyze the largest set of tumor samples to date using state-of-the-art genomic and molecular techniques. Memorial Sloan-Kettering currently houses one of TCGA's Genome Data Analysis Centers, led by computational biologist Chris Sander, PhD, biocomputing manager Nikolaus Schultz, PhD, and molecular pathologist Marc Ladanyi, MD. For the endometrial cancer study, Memorial Sloan-Kettering contributed more than 10 percent of all tissue samples analyzed.

###

This research was supported by the National Cancer Institute of the National Institutes of Health (NIH) under award 5U24CA143840-04.

Memorial Sloan-Kettering Cancer Center is the world's oldest and largest private institution devoted to prevention, patient care, research, and education in cancer. Our scientists and clinicians generate innovative approaches to better understand, diagnose, and treat cancer. Memorial Sloan-Kettering specialists are leaders in biomedical research and in translating the latest research to advance the standard of cancer care worldwide. For more information, go to http://www.mskcc.org.


[ Back to EurekAlert! ] [ | E-mail | Share Share ]

?


AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.


Source: http://www.eurekalert.org/pub_releases/2013-05/mscc-lgs050113.php

arbor day mike adams janoris jenkins john edwards trial brandon weeden felicia day nfl 2012 draft

2-year-old girl gets windpipe made from stem cells

CHICAGO (AP) ? A 2-year-old girl born without a windpipe now has a new one grown from her own stem cells, the youngest patient in the world to benefit from the experimental treatment.

Hannah Warren has been unable to breathe, eat, drink or swallow on her own since she was born in South Korea in 2010. Until the operation at a central Illinois hospital, she had spent her entire life in a hospital in Seoul. Doctors there told her parents there was no hope and they expected her to die.

The stem cells came from Hannah's bone marrow, extracted with a special needle inserted into her hip bone. They were seeded in a lab onto a plastic scaffold, where it took less than a week for them to multiply and create a new windpipe.

About the size of a 3-inch tube of penne pasta, it was implanted April 9 in a nine-hour procedure.

Early signs indicate the windpipe is working, Hannah's doctors announced Tuesday, although she is still on a ventilator. They believe she will eventually be able to live at home and lead a normal life.

"We feel like she's reborn," said Hannah's father, Darryl Warren.

"They hope that she can do everything that a normal child can do but it's going to take time. This is a brand new road that all of us are on," he said in a telephone interview. "This is her only chance but she's got a fantastic one and an unbelievable one."

Warren choked up and his wife, Lee Young-mi, was teary-eyed at a hospital news conference Tuesday. Hannah did not attend because she is still recovering from the surgery. She developed an infection after the operation but now is acting like a healthy 2-year-old, her doctors said.

Warren said he hopes the family can bring Hannah home for the first time in a month or so. Hannah turns 3 in August.

"It's going to be amazing for us to finally be together as a family of four," he said. The couple has an older daughter.

Only about one in 50,000 children worldwide are born with the windpipe defect. The stem-cell technique has been used to make other body parts besides windpipes and holds promise for treating other birth defects and childhood diseases, her doctors said.

The operation brought together an Italian surgeon based in Sweden who pioneered the technique, a pediatric surgeon at Children's Hospital of Illinois in Peoria who met Hannah's family while on a business trip to South Korea, and Hannah ? born to a Newfoundland man and Korean woman who married after he moved to that country to teach English.

Hannah's parents had read about Dr. Paolo Macchiarini's success using stem-cell based tracheas but couldn't afford to pay for the operation at his center, the Karolinska Institute in Stockholm. So Dr. Mark Holterman helped the family arrange to have the procedure at his Peoria hospital, bringing in Macchiarini to lead the operation. Children's Hospital waived the cost, likely hundreds of thousands of dollars, Holterman said.

Part of OSF Saint Francis Medical Center, the Roman Catholic hospital considers the operation part of their mission to provide charity care, but also views it as a way to champion a type of stem-cell therapy that doesn't involve human embryos, the surgeons said. The Catholic church opposes using stem cells derived from human embryos in research or treatment.

Macchiarini has been involved in 14 previous windpipe operations using patients' own stem cells ? five using man-made scaffolds like Hannah's but in adults; and nine using scaffolds made from cadaver windpipes, including one in a 10-year-old British boy.

He said only one patient died, a 30-year-old man from Abingdon, Md., who had the operation in November 2011 to treat late-stage cancer of the windpipe. He died about four months later of uncertain causes, Macchiarini said.

Similar methods have been used to grow bladders, urethras and last year a girl in Sweden got a lab-made vein using her own stem cells and a cadaver vein.

Scientists hope to eventually use the method to create solid organs, including kidneys and livers, said Dr. Anthony Atala, director of Wake Forest University's Institute for Regenerative Medicine. He said the operation on Hannah Warren "is really showing that the technique is workable."

Hannah had breathing difficulties at birth and Korean doctors soon discovered the missing windpipe. They reconfigured her esophagus so that a breathing tube could go down it from her mouth to her lungs. The esophagus normally runs behind the windpipe and carries food to the stomach.

Korean doctors said she couldn't live long with the tube and told her parents there was nothing more they could do.

Hannah outlived their expectations and has thrived despite the grim prognosis and other abnormalities including an undeveloped voice box that prevented her from speaking. Now that she has a windpipe and can breathe more normally, doctors expect the larynx to grow and function normally. She will work with speech therapists to help her learn to talk.

Holterman said Hannah will likely need a new windpipe in about five years, as she grows.

She breathes with help from a ventilator but no longer has a tube in her mouth that she'd lived with since shortly after birth, Holterman said. She's not yet able to eat normally, but doctors let her have her first taste ever of food ? a few licks on a lollipop. Her father said she already has discriminating taste and prefers chocolate Korean lollipops to the American kind.

"I asked her, 'Is it good?'" he said, "and she immediately nodded her head."

___

Online:

Regenerative Medicine: http://1.usa.gov/13IWdrx

___

AP Medical Writer Lindsey Tanner can be reached at http://www.twitter.com/LindseyTanner

Source: http://news.yahoo.com/2-old-girl-gets-windpipe-made-stem-cells-154952354.html

Nazanin Boniadi Deval Patrick Dedication 4 labor day college football scores khan academy Espn College Football

Packaged Chrome apps now searchable in dev channels for Chrome OS and Windows

Packaged Chrome apps now available on Dev Channels for Chrome OS and Windows

While Google opened the door to packaged Chrome apps back in February, it's been a largely one-way affair ever since -- developers could upload the native-style apps, but they couldn't find anything without a direct link. As of a dev channel update, the relationship is a little more two-directional. Both Chrome OS and Windows-based Chrome testers can at last search for packaged apps in the Chrome Web Store alongside the usual releases. Google is mostly holding back on wider access to give developers more time to polish their work. Us non-coders will have to be patient, then, but truly offline-friendly apps just came one step closer.

Filed under: , ,

Comments

Via: Chromium Blog

Source: Chromium Projects

Source: http://www.engadget.com/2013/05/02/packaged-chrome-apps-now-discoverable-in-dev-channels/?utm_medium=feed&utm_source=Feed_Classic&utm_campaign=Engadget

uganda the parent trap invisible children kony 2012 space weather sunspots pac 12 tournament sun storm

Google Glass Bulletproof app gives the wearable a lock screen (video)

Google Glass Bulletproof app gives the wearable a lock screen (video)

In our review of the Explorer edition of Google Glass, we were surprised at the lack of security features -- there's nothing to stop anyone from picking up your pair, accessing your data and having complete control. We're obviously not the only ones to have noticed this, and developer Mike DiGiovanni, who has his own set of high-tech specs, has come up with an app to alleviate those worries. Called Bulletproof, the app registers when Glass parts from face and engages a lock screen, which can then be disabled with a user-defined combination of swipes and taps on the wearable's touchpad. A brief video demo of the app is available below, and those with the hardware will likely know how to get it loaded using the files linked at the source. It's good to see the dev community already putting out useful software, but it does make you wonder why Google didn't think of it first.

Filed under: , ,

Comments

Via: SlashGear

Source: Mike DiGiovanni (Google+)

Source: http://feeds.engadget.com/~r/weblogsinc/engadget/~3/dNl9CURPxNY/

Ron Jeremy Rudy Gay Jim Nabors The Americans bank of america online banking Adairsville Ga ashley judd

Wednesday, May 1, 2013

Kerry seeks Arab support for Israeli-Palestinian peace

WASHINGTON (Reuters) - U.S. Secretary of State John Kerry met a group of senior Arab officials on Monday as he sought to build regional support for any fresh push for Israeli-Palestinian peace.

Kerry has made no secret of his hope to revive peace talks, which broke down in 2010, but it remains unclear whether U.S. President Barack Obama will decide to back a major U.S. effort.

In convening the group, Kerry is trying to ensure that a new peace process would have the backing of the Arab states, who, if they were to offer Israel a comprehensive peace, hold a powerful card that could provide an incentive for Israeli compromises.

After meeting the Bahraini, Egyptian, Jordanian and Qatari foreign ministers as well as with officials from Lebanon, Saudi Arabia, the Palestinian Authority and the Arab League, Kerry and the Arab states voiced support for a 2002 Arab League peace initiative.

"I underscored the Arab League's very important role ... by reaffirming the Arab Peace Initiative here this afternoon," Kerry told reporters after the talks at Blair House, the U.S. president's guest house. U.S. Vice President Joe Biden attended part of the meeting.

The Arab League proposal offered full Arab recognition of Israel if it gave up land seized in a 1967 war and accepted a "just solution" for Palestinian refugees.

Rejected by Israel when it was originally proposed at a Beirut summit in 2002, the plan has major hurdles to overcome.

Israel objects to key points, including a return to 1967 borders, the inclusion of Arab East Jerusalem in a Palestinian state and the return Palestinian refugees to what is now Israel.

"The Arab League delegation understands that peace between the Palestinians and the Israelis is ... a strategic choice for the Arab states," Sheikh Hamad bin Jassim al-Thani, who serves as Qatar's prime minister and foreign minister, told reporters.

The core issues that need to be settled in the more than six-decade dispute include borders, the fate of Palestinian refugees, the future of Jewish settlements on the West Bank and the status of Jerusalem.

(Reporting By Arshad Mohammed; Editing by David Brunnstrom)

Source: http://news.yahoo.com/kerry-seeks-build-arab-support-israeli-palestinian-peace-003641722.html

elvis presley elvis presley Pretty Little Liars Rob Parker Comcast Pokemon X and Y Rob Ryan

Kaley Cuoco: New Hairdo Caused By Forehead Gash!

Source: http://www.thehollywoodgossip.com/2013/04/kaley-cuoco-new-hairdo-caused-by-forehead-gash/

Chechen Boston bombers chechnya live news nbc UMass Dartmouth Katherine Russell

The Mortal Instruments City of Bones International Trailer: Arrived!

Source: http://www.thehollywoodgossip.com/2013/04/the-mortal-instruments-city-of-bones-international-trailer-arriv/

lone ranger aaron brooks dave matthews band solar flares 2012 whitney houston will toyota recall northern lights

Tuesday, April 30, 2013

Jon Jones, Pat Healy and Sara McMann: UFC 159?s Three Stars

UFC 159 was a bizarre event ? possibly cursed by demons ? but there were still plenty of standout performances by fighters whose bouts ended normally. Who stood out for you? Speak up on Twitter or on Facebook.

No. 1 star -- Jon Jones: As we've said since the fight was made, Chael Sonnen was not the right competition for UFC light heavyweight Jones because he is middleweight coming off of a loss. Jones could have taken Sonnen lightly and still probably won, but he didn't do that. He used the fight as another opportunity to show his dominance, beating Sonnen at his own game by taking him down several times before finishing the fight near the end of the first round.

Would the fight have been stopped if they made it out of the first round, and the referee had noticed Jones' mangled toe? Who cares? It didn't happen, and Jones is still the champ.

No. 2 star -- Pat Healy: The UFC's already stacked lightweight division somehow got even tough with Healy's performance on Saturday night. Along with Jim Miller, he put on a show then finished the fight in the third round. He won both Fight of the Night and Submission of the Night, meaning Healy walked away with an extra $130,000.

No. 3 star -- Sara McMann: As an Olympic silver medal-winning wrestler, McMann is one of the most decorated athletes to join the UFC. This means she had big expectations to perform, and she exceeded them. McMann used wrestling and power to stop Sheila Gaff in the first round.

More news from the Yahoo! Sports Minute:

Other popular content on Yahoo! Sports:
? Jets show disdain for Tim Tebow
? ThePostGame: The road to Jason Collins' revelation
? Just how big is Jimmie Johnson?s points lead?

Source: http://sports.yahoo.com/blogs/mma-cagewriter/jon-jones-pat-healy-sara-mcmann-ufc-159-132329967.html

peeps nhl playoffs 2012 masters shroud of turin the borgias the masters warren sapp

Amped Wireless' TAN 1 WiFi adapter for Windows 8 arriving for $60

Amped Wireless TAN 1 WiFi adapter for Windows 8 arrives today

Amped Wireless' long-gestating TAN 1 may look like a chocolate bar, but you'd probably regret dunking it in your coffee. The high-powered WiFi adapter connects over USB to Windows 8 laptops and tablets, promising to triple the range of your device's built-in wireless gear. After what seems like an age, the hardware is finally making its way to stores, and will set you back $59.99 when it goes on sale today!.

Filed under:

Comments

Source: Amped Wireless

Source: http://www.engadget.com/2013/04/30/amped-tan1-retail/?utm_medium=feed&utm_source=Feed_Classic&utm_campaign=Engadget

tom brady denver post Scandal denver broncos new england patriots Zayn Malik miss america

Sprint seeks details from Dish on takeover proposal

By Liana B. Baker and Ben Berkowitz

(Reuters) - Sprint Nextel Corp on Monday said its merger partner, SoftBank Corp, has waived some terms of their agreement so that Sprint can seek more information from rival suitor Dish Network Corp.

The exchange of information between Sprint and Dish indicates the companies are in conversations about the satellite broadcaster's $25.5 billion takeover bid, even if Sprint for now is standing by its $20.1 billion pact with SoftBank.

Dish said it had received a Sprint request for more information about the bid, and a non-disclosure agreement that would keep such information private.

Dish said it had already given some information to Sprint in response to requests from a Sprint special committee.

SoftBank said the waiver it granted does not allow Sprint to disclose nonpublic information or negotiate with Dish.

But Dish said it looks "forward to being able to conduct confirmatory due diligence as soon as possible" with Sprint.

Dish shocked markets two weeks ago with its cash and stock offer for Sprint, which it claimed was superior to the deal SoftBank and Sprint struck last October. Sprint said it had formed a special board committee and hired advisers to consider the Dish bid. But it also said it was still on track to close its deal with SoftBank by July 1.

SoftBank, in a statement, said it had issued the waiver at the request of Sprint's special committee and reiterated its intent to proceed with the deal.

"SoftBank remains highly confident that its fully executed merger agreement with Sprint, under which it has already provided Sprint with $3.1 billion of capital, provides the shareholders of Sprint significantly more value than the highly leveraged approach made by Dish on April 15th," it said.

Dish Chairman Charlie Ergen said in a statement that Dish was "confident that the Sprint Board will share our view that this proposal is superior by offering Sprint shareholders greater value with a higher price and more cash."

Dish shares were up 0.8 percent at $40.32 in afternoon trading, while Sprint shares were off 1 cent at $7.11.

(Reporting By Liana B. Baker and Ben Berkowitz; Editing by Maureen Bavdek, Sofina Mirza-Reid and John Wallace)

Source: http://news.yahoo.com/softbank-amends-sprint-deal-terms-dish-inquiry-123148013.html

Ben Wilson Latest Presidential Polls trump presidential debate debate marco scutaro Russell Means

Researchers design nanometer-scale material that can speed up, squeeze light

Apr. 29, 2013 ? In a process one researcher compares to squeezing an elephant through a pinhole, researchers at Missouri University of Science and Technology have designed a way to engineer atoms capable of funneling light through ultra-small channels.

Their research is the latest in a series of recent findings related to how light and matter interact at the atomic scale, and it is the first to demonstrate that the material -- a specially designed "meta-atom" of gold and silicon oxide -- can transmit light through a wide bandwidth and at a speed approaching infinity. The meta-atoms' broadband capability could lead to advances in optical devices, which currently rely on a single frequency to transmit light, the researchers say.

"These meta-atoms can be integrated as building blocks for unconventional optical components with exotic electromagnetic properties over a wide frequency range," write Dr. Jie Gao and Dr. Xiaodong Yang, assistant professors of mechanical engineering at Missouri S&T, and Dr. Lei Sun, a visiting scholar at the university. The researchers describe their atomic-scale design in the latest issue of the journal Physical Review B.

The researchers created mathematical models of the meta-atom, a material 100 nanometers wide and 25 nanometers tall that combined gold and silicon oxide in stairstep fashion. A nanometer is one billionth of a meter and visible only with the aid of a high-power electron microscope.

In their simulations, the researchers stacked 10 of the meta-atoms, then shot light through them at various frequencies. They found that when light encountered the material in a range between 540 terahertz and 590 terahertz, it "stretched" into a nearly straight line and achieved an "effective permittivity" known as epsilon-near-zero.

Effective permittivity refers to the ratio of light's speed through air to its speed as it passes through a material. When light travels through glass, for instance, its effective permittivity is 2.25. Through air or the vacuum of outer space, the ratio is one. That ratio is what is typically referred to as the speed of light.

As light passes through the engineered meta-atoms described by Gao and Yang, however, its effective permittivity reaches a near-zero ratio. In other words, through the medium of these specially designed materials, light actually travels faster than the speed of light. It travels "infinitely fast" through this medium, Yang says.

The meta-atoms also stretch the light. Other materials, such as glass, typically compress optical waves, causing diffraction.

This stretching phenomenon means that "waves of light could tunnel through very small holes," Yang says. "It is like squeezing an elephant through an ultra-small channel."

The wavelength of light encountering a single meta-atom is 500 nanometers from peak to peak, or five times the length of Gao and Yang's specially designed meta-atoms, which are 100 nanometers in length. While the Missouri S&T team has yet to fabricate actual meta-atoms, they say their research shows that the materials could be built and used for optical communications, image processing, energy redirecting and other emerging fields, such as adaptive optics.

Last year, Albert Polman at the FOM Institute for Atomic and Molecular Physics in Amsterdam and Nader Engheta, an electrical engineer at the University of Pennsylvania, developed a tiny waveguide device in which light waves of a single wavelength also achieved epsilon-near-zero. But the Missouri S&T researchers' work is the first to demonstrate epsilon-near-zero in a broadband of 50 terahertz.

"The design is practical and realistic, with the potential to fabricate actual meta-atoms," says Gao. Adds Yang: "With this research, we filled the gap from the theoretical to the practical."

Through a process known as electron-beam deposition, the researchers have built a thin-film wafer from 13 stacked meta-atoms. But those materials were uniform in composition rather than arranged in the stairstep fashion of their modeled meta-atoms.

Share this story on Facebook, Twitter, and Google:

Other social bookmarking and sharing tools:


Story Source:

The above story is reprinted from materials provided by Missouri University of Science and Technology. The original article was written by Andrew Careaga.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.


Journal Reference:

  1. Lei Sun, Jie Gao, Xiaodong Yang. Broadband epsilon-near-zero metamaterials with steplike metal-dielectric multilayer structures. Physical Review B, 2013; 87 (16) DOI: 10.1103/PhysRevB.87.165134

Note: If no author is given, the source is cited instead.

Disclaimer: Views expressed in this article do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/strange_science/~3/RFnsUhSDhLc/130429094646.htm

Spain Vs Italy Euro 2012 Pepco erin andrews erin andrews tour de france Magic Mike Anderson Cooper Gay

New methods to explore astrocyte effects on brain function

New methods to explore astrocyte effects on brain function [ Back to EurekAlert! ] Public release date: 29-Apr-2013
[ | E-mail | Share Share ]

Contact: Rita Sullivan King
news@rupress.org
212-327-8603
Rockefeller University Press

A study in The Journal of General Physiology presents new methods to evaluate how astrocytes contribute to brain function, paving the way for future exploration of these important brain cells at unprecedented levels of detail.

Astrocytesthe most abundant cell type in the human brainplay crucial roles in brain physiology, which may include modulating synaptic activity and regulating local blood flow. Existing research tools can be used to monitor calcium signals associated with interactions between astrocytes and neurons or blood vessels. Until now, however, astrocytic calcium signals have been investigated mainly in their somata (cell bodies) and large processes, rather than in distal fine processes close to neuronal synapses or the endfeet that surround blood vessels. Previous studies have also mainly investigated immature specimens rather than mature brain cells.

Now, a team of California researchers provides detailed methods to visualize calcium signals throughout entire astrocytes in hippocampal slices from adult mice. The team observed numerous spontaneous localized calcium signals throughout the entire astrocyte, including the branchlets and endfeet. Their results indicated that calcium signals in endfeet were independent of those in somata and occurred more frequently. In addition to the specific findings, their methods can be used in future studies to advance our understanding of the physiology of astrocytes and their interactions with neurons and the microvasculature of the brain.

###

About The Journal of General Physiology

Founded in 1918, The Journal of General Physiology (JGP) is published by The Rockefeller University Press. All editorial decisions on manuscripts submitted are made by active scientists in conjunction with our in-house scientific editor. JGP content is posted to PubMed Central, where it is available to the public for free six months after publication. Authors retain copyright of their published works and third parties may reuse the content for non-commercial purposes under a creative commons license. For more information, please visit http://www.jgp.org.

Shigetomi, E., et al. 2013. J. Gen. Physiol. doi:10.1085/jgp.201210949. Adler, E. 2013. J. Gen. Physiol. doi:10.1085/jgp.201311002.


[ Back to EurekAlert! ] [ | E-mail | Share Share ]

?


AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.


New methods to explore astrocyte effects on brain function [ Back to EurekAlert! ] Public release date: 29-Apr-2013
[ | E-mail | Share Share ]

Contact: Rita Sullivan King
news@rupress.org
212-327-8603
Rockefeller University Press

A study in The Journal of General Physiology presents new methods to evaluate how astrocytes contribute to brain function, paving the way for future exploration of these important brain cells at unprecedented levels of detail.

Astrocytesthe most abundant cell type in the human brainplay crucial roles in brain physiology, which may include modulating synaptic activity and regulating local blood flow. Existing research tools can be used to monitor calcium signals associated with interactions between astrocytes and neurons or blood vessels. Until now, however, astrocytic calcium signals have been investigated mainly in their somata (cell bodies) and large processes, rather than in distal fine processes close to neuronal synapses or the endfeet that surround blood vessels. Previous studies have also mainly investigated immature specimens rather than mature brain cells.

Now, a team of California researchers provides detailed methods to visualize calcium signals throughout entire astrocytes in hippocampal slices from adult mice. The team observed numerous spontaneous localized calcium signals throughout the entire astrocyte, including the branchlets and endfeet. Their results indicated that calcium signals in endfeet were independent of those in somata and occurred more frequently. In addition to the specific findings, their methods can be used in future studies to advance our understanding of the physiology of astrocytes and their interactions with neurons and the microvasculature of the brain.

###

About The Journal of General Physiology

Founded in 1918, The Journal of General Physiology (JGP) is published by The Rockefeller University Press. All editorial decisions on manuscripts submitted are made by active scientists in conjunction with our in-house scientific editor. JGP content is posted to PubMed Central, where it is available to the public for free six months after publication. Authors retain copyright of their published works and third parties may reuse the content for non-commercial purposes under a creative commons license. For more information, please visit http://www.jgp.org.

Shigetomi, E., et al. 2013. J. Gen. Physiol. doi:10.1085/jgp.201210949. Adler, E. 2013. J. Gen. Physiol. doi:10.1085/jgp.201311002.


[ Back to EurekAlert! ] [ | E-mail | Share Share ]

?


AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.


Source: http://www.eurekalert.org/pub_releases/2013-04/rup-nmt042913.php

2012 Olympics Chad Everett London Olympics Kristen Stewart Rupert Sanders Photos 2016 Olympics TD Bank mountain lion